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Sleep Quality and Its Impact on Glucose Metabolism in Alzheimer's Disease

Have you ever woken up after a restless night's sleep and felt like your brain was in a fog? It's not just your imagination. The quality of your sleep can have a profound impact on your brain health. A recent study titled "Differential effects of sleep on brain structure and metabolism at the preclinical stages of AD" delves into this intriguing subject, revealing how sleep quality might influence the structure and metabolism of your brain, particularly in the context of Alzheimer's disease (AD).

The study found that poor self-reported sleep quality was associated with changes in brain structure and metabolism, particularly in individuals at the preclinical stages of AD. The researchers observed that individuals with amyloid-beta (Aβ) pathology (A+) and without tau pathology (T−), as well as those with both Aβ and tau pathologies (A+T+), had larger grey matter volume (GMv) compared to the reference group without either pathology (A−T−). These changes were noted in bilateral temporal and parietal regions.

Interestingly, lower GMv was found in bilateral frontal and right temporal regions in A+T+ individuals compared to A+T− groups. The study also found higher glucose metabolism in A+T+ individuals, compared to A+T− and A−T− groups, in widespread bilateral cortical and subcortical regions, involving frontal, temporal, parietal, and occipital lobes, and the thalami.

What's more, poorer outcomes in several sleep quality metrics were significantly associated with lower GMv in a composite region. These metrics included sleep quality (fairly bad vs. good), sleep latency (31-60 minutes vs. <15 minutes and >60 minutes vs. <15 minutes), sleep duration (<5 hours vs. >7 hours), and sleep efficiency (75% to 84% vs. >85%).

These findings underscore the importance of good sleep quality in maintaining brain health, particularly in the context of Alzheimer's disease. As we continue to learn more about the complex relationship between sleep and brain health, it's clear that prioritizing good sleep hygiene is an essential part of a proactive approach to cognitive wellness.

Here at Neurobit, we're not just committed to helping individuals understand and improve their sleep health. We're also dedicated to facilitating the discovery of novel biomarkers in the academic and research communities. Our Neurobit Hub is specifically designed for this purpose. It's an end-to-end platform for data collection and AI scoring, making it an invaluable tool for researchers studying sleep and its impact on various health outcomes. Our Z3 Pulse, a wearable ECG device, delivers detailed sleep reports with personalized guidance. It's clinically validated and provides consistent results relative to the gold standard in the field, polysomnography (PSG). By monitoring your sleep patterns with the Z3 Pulse, you can gain insights into your sleep quality and take steps to improve it, potentially reducing your risk of cognitive impairment.

For more information about Neurobit's technologies or to learn how we can help accelerate your research and improve sleep health, please contact us.


Stankeviciute, L., Falcon, C., Operto, G., Garcia, M., Shekari, M., Iranzo, Á., Niñerola‐Baizán, A., Perissinotti, A., Minguillón, C., Fauria, K., Molinuevo, J. L., Zetterberg, H., Blennow, K., Suárez‐Calvet, M., Cacciaglia, R., Gispert, J. D., Grau‐Rivera, O., & and for the ALFA study. (2023). Differential effects of sleep on brain structure and metabolism at the preclinical stages of AD. Alzheimer’s & Dementia, alz.13102.

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